Structure Inner mitochondrial membrane

for typical liver mitochondria, area of inner membrane 5x large outer membrane due cristae. ratio variable , mitochondria cells have greater demand atp, such muscle cells, contain more cristae. cristae membranes studded on matrix side small round protein complexes known f1 particles, site of proton-gradient driven atp synthesis. cristae affect overall chemiosmotic function of mitochondria.

cristae junctions

cristae , inner boundary membranes separated junctions. end of cristae partially closed transmembrane protein complexes bind head head , link opposing crista membranes in bottleneck-like fashion. example, deletion of junction protein mitofilin/fcj1 leads reduced inner membrane potential , impaired growth , dramatically aberrant inner membrane structures form concentric stacks instead of typical invaginations.