Gene C11orf73

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1 gene

1.1 alternative splicing
1.2 promoter
1.3 termination





gene

chromosome 11 open reading frame 73 protein-coding gene in homo sapiens. alternate names gene flj43020, hspc138, hspc179, , l7rn6. located on long arm of chromosome 11 @ area q14.2, entire gene including introns , exons 42,698 base pairs on plus strand. mrna of c11orf73 variant 1 includes exons 1, 3, 4, 5, , 7 amounting 1,183 base pairs, base pairs 239 832 representing coding regions.


alternative splicing

variant 1 longest , common protein coding variant. 3 other main variants use alternate exon sequence throws off reading frame, causing termination of mrna sequence , undergoes protein decay. table below shows different variants , exon usage.



the 4 variants shown in table above common isoforms found in human cells. there total of 13 alternatively spliced sequences , 3 unspliced forms utilize 2 alternative promoters. mrna variants differ on combination of 8 different exons, alternate, overlapping exons, , retention of introns. besides alternative spilcing, mrnas differ truncation on 3’ end. variant 1 one of ten mrnas has been shown code protein, while rest seem bound nonsense mediated mrna decay. aceview representation of c11orf73 isoforms


promoter

the promoter region, gxp 47146, found using eldorado tool genomatix. 840 bp sequence located before c11orf73 gene @ dna points 86012753 86013592. promoter conserved in 12 of 12 orthologs , codes 6 relevant transcripts.


conserved transcription factor binding sites genomatix eldorado tool:




predicted promoter region of c11orf73



termination

termination of mrna product encoded within cdna of gene. end termination of mrna product has 3 main features: poly signal, poly tail, , area of sequence can form stem loop structure. poly signal highly conserved site, 6 nucleotide long sequence. in eukaryotes sequence aataaa , located 10-30 nucleotides poly site. aataaa sequence highly conserved, eukaryotic polya signal signals polyadenylation of mrna product 10-30 base pairs after signal sequence. polya site c11orf73 gta.








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