Tissue damaged by inflammation Healing

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1 tissue damaged inflammation

1.1 recall phase
1.2 resolution phase
1.3 regeneration phase
1.4 repair phase





tissue damaged inflammation

after inflammation has damaged tissue (when combatting bacterial infection example) , pro-inflammatory eicosanoids have completed function, healing proceeds in 4 phases.


recall phase

in recall phase adrenal glands increase production of cortisol shuts down eicosanoid production , inflammation.


resolution phase

in resolution phase, pathogens , damaged tissue removed macrophages (white blood cells). red blood cells removed damaged tissue macrophages. failure remove of damaged cells , pathogens may retrigger inflammation. 2 subsets of macrophage m1 & m2 plays crucial role in phase, m1 macrophage being pro inflammatory while m2 regenerative , plasticity between 2 subsets determine tissue inflammation or repair.


regeneration phase

in regeneration phase, blood vessels repaired , new cells form in damaged site similar cells damaged , removed. cells such neurons , muscle cells (especially in heart) slow recover.


repair phase

in repair phase, new tissue generated requires balance of anti-inflammatory , pro-inflammatory eicosanoids. anti-inflammatory eicosanoids include lipoxins, epi-lipoxins, , resolvins, cause release of growth hormones.








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