Use of and common targets in detection in different leukaemias.2C lymphomas and solid tumors Minimal residual disease

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1 use of , common targets in detection in different leukaemias, lymphomas , solid tumors

1.1 acute lymphoblastic leukaemia (all)
1.2 acute myeloid leukaemia (aml)
1.3 chronic lymphocytic leukaemia
1.4 chronic myelogenous leukemia
1.5 follicular lymphoma
1.6 mantle cell lymphoma
1.7 multiple myeloma
1.8 solid tumors
1.9 animal species other humans





use of , common targets in detection in different leukaemias, lymphomas , solid tumors
acute lymphoblastic leukaemia (all)

targets: t(9;22) bcr-abl, t(12;21) etv6-runx1 (tel-aml1), patient specific assays immunoglobulin , t cell receptor genes


uses: chromosomal translocation mrd detection used standard clinical practice. patient specific assays gaining acceptance still used in research protocols.


acute myeloid leukaemia (aml)

targets: t(15;17) pml-rara, t(8;21) aml1-runx1t1 (aml-eto), inv(16)


uses: chromosomal translocation mrd detection used standard clinical practice.


chronic lymphocytic leukaemia

targets: cell surface proteins, patient-specific assays immunoglobulin , t cell receptor genes


uses: immunological methods gaining wider use more advanced flow cytometers utilized clinical testing. patient specific assays still used in research protocols.


chronic myelogenous leukemia

target: t(9;22) bcr-abl


uses: mrd detection of t(9;22) considered standard of care patients cml , extremely valuable patients being treated imatinib mesylate (gleevec/glivec).


follicular lymphoma

targets: t(14;18) igh/bcl2, patient specific assays immunoglobulin , t cell receptor genes.


uses: t(14;18) regularly used mrd detection. patient specific assays still used in research protocols.


mantle cell lymphoma

targets: t(11;14) igh/ccnd1 (igh/bcl1), patient-specific assays immunoglobulin , t cell receptor genes


uses: t(11;14) regularly used mrd detection, assay can reliably detect 40–60% of t(11;14) translocations. patient-specific assays still used in research protocols.


multiple myeloma

targets: m-protein levels in blood, patient-specific assays immunoglobulin , t cell receptor genes (high levels of somatic hypermutation prevent assay reliably working).


uses: m-protein level in blood standard of care , used patients multiple myeloma. patient-specific assays still used in research protocols.


solid tumors

research mrd detection of several solid tumors such breast cancer , neuroblastoma has been performed. these assays have been used sample lymph nodes , blood residual or metastatic tumor cells. applicable targets mrd detection have been more difficult determine in solid tumors , use of mrd in solid tumors less advanced use in leukemia , lymphoma.


animal species other humans

leukaemias , lymphomas potentially monitored in non-human animals, however, no known evidence of such veterinary applications exists date.







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